A recent study has shown that broccoli sprout extract, rich in sulforaphane, may play a role in improving blood sugar levels in certain individuals, particularly those with a specific gut microbiome composition.

However, the effectiveness of this extract varies from person to person, opening the door to the development of personalized treatments based on gut microbiome analysis.

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One in three adults worldwide has prediabetes, yet most are unaware of their condition.

According to “News Medical,” prediabetes is a condition where blood sugar levels are between normal and diabetic thresholds.

Up to 70% of people with prediabetes may develop type 2 diabetes, a common disease that increases the risk of cardiovascular diseases and metabolic disorders.

Recent research has identified the role of gut microbiota in regulating blood sugar levels, suggesting that microbial composition may affect individuals’ responses to dietary interventions.

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Sulforaphane, found in broccoli sprout extract, has shown potential in reducing glucose production in the liver, but its effectiveness in prediabetes remains uncertain.

Understanding the combined effect of broccoli sprout extract (BSE) and gut microbiota on glucose regulation is essential for developing personalized interventions.

Additionally, recent findings suggest that the ability to activate sulforaphane may depend on specific bacterial genes in the gut, such as the BT2160 gene, which plays a crucial role in converting inactive sulforaphane precursors into their active form.

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The study was conducted on individuals with prediabetes who had never taken medication before. Participants, aged 35 to 75 years, had elevated glucose levels (6.1–6.9 mmol/L) and a body mass index (BMI) between 27 and 45 kg/m².

The study also found that the presence of the BT2160 gene in gut microbiota was associated with increased sulforaphane effectiveness.

The results concluded that broccoli sprout extract could be beneficial for certain individuals, particularly those with a specific gut microbiota composition and the BT2160 gene.

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